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Gil, You've asked some good questions, one's I would like to know too. Ben & I just can't see any "on or off" times. The only thing I can answer is that Ben was put on Tasmar last month & it seems to be helping quite a bit with his tremor. It didn't seem to help with his problem of equilibrium. He is taking 50/200 Sinemet CR twice a day & Tasmar 100 mg. three times a day. I have to add that the meds work well as long as he's not under pressure. Linda CG for Ben 68/4 [log in to unmask]