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Hi Gil and Aliza, and Art-- You could be taking both not enought Sinemet, or too much Tasnar! I use 225 mg per day. With the aid of a pill-cutter, I take 25mg, 50, 50, 50 and 50 mg. These five doses are spread out from mid-morning to midnight. We cut up 100 mg tablets. I can get tired after these much lesser dosages, but in general they extend my Sinemet significantly. My Sinemet is down to 750-800 -was 1500 mg / day. Yesterday I was on without an off-period for SIX hours-triple the expected Sinemet on-off cycle. Unfortunately, my food digestion is so slow that my pill pieces may get blocked from being useful. At those times, I have to lie down and wait for a long time, or sit quietly, and sip water or orange juice, unless I sleep. I also do NOT take Tasmar until my 2nd dose of the day. Otherwise, I will get very tired, and hear a buzzing sound that bothers me and distracts me. All in all, Tasmar (tolcapone) has nonetheless been a wonderful drug for me-and has prevented me from thinking about pallidotomy. Ivan 48/12 ^^^^^^WARM GREETINGS FROM^^^^^^^^^^^^^^^^^ Ivan Suzman 48/12 [log in to unmask] Portland, Maine Land of lighthouses 74 deg. F ******************************************************************** On Sun, 23 Aug 1998 15:51:23 +0300 Gil Lieberman <[log in to unmask]> writes: >Art, >This is in response to your message below. >My wife Aliza is on the same PD meds as you and is experiencing the >same Tasmar side-effect of being very tired.After about six weeks >of Tasmar and about two weeks of 200mgx3,we have concluded that Tasmar >is not helping her PD and is producing the following side-effects: >1.Extreme tiredness >2.Increased tremor. >3.Shakiness >4.Sharp drops in blood pressure. > >Gil,CG for Aliza,PD 2/95 >--------------------------------- >Date: Fri, 21 Aug 1998 09:30:24 EDT >From: Art D'Isabel <[log in to unmask]> >Subject: Re: Tasmar > >Shortly after taking a 200mg tablet of Tasmar, I get so tired that I >find it >difficult to stay awake. I take 200 mg of Tasmar three times a day, >as well >as my regular dose of sinemet and caridopa/levodapa. Does anyone else >who is >on Tasmar experience the same side effect? >