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Help - I'm having severe 'down times' and am looking for ANY suggestions or ideas. I was taking 1 sinemet 25/100 about every 1 to 1 1/2 hours, .5 mg of Permax 3 times a day, one 5 mg Eldepryl, plus a vitamin C daily. I was starting to experience longer down times than I was used to - before, I could pop a 25/100 Sinemet and with-in 15-30 min's I was back to functioning. Then my nuerologist decided that maybe 50/200 Sinemet CR (time released) would level out the down times, so he switched me to CR, plus I upped the Permax from .5 to .75 mg (still 3 times a day). At 1st, it wasn't so bad, but then I noticed that when I 1st got up, the med's were taking longer to get me going. So, I called the nuero and convinced him to let me take (in addition) 1-2 25/100 Sinemet 1st thing in the morning. That seemed to work, at least for getting me moving (unfrozen) 1st thing in the mornings. I ran out of the 25/100's and decided that I should REALLY try to get by without them. My down time (frozen) has continued to worsen, to the point now where it may take me 2-4 hours to get out of the frozen state - now, if I forget to take my med's, I can expect a longggg down time. This sudden drastic change is scaring me - am I doing something wrong, has my PD taken a turn for the worse, or what? What else is different? I just had disc surgery and can't sit for 6 weeks. No med's, just have to take it easy. HELP - mark