Hi Maark First let me say - been there, done that - still doing that. However, I have had a little relief, Mainly by mamging what I eat and when. I suppose you have tried to do the arithmetic - how can you take sinemet an hour before eating and two hours after eating if you have to take it every hour and a half?. I eat as little as possible during the day - that is , I don't starve - a high bran content breakfast with fruit, fruit or salad for lunch and then dinner I have a 1 to 7 ratio protein and veg. And I cheat plenty - but I try not to eat close to taking sinemet. I've recently changed form permax to meripax, and I take half of a sinemet CR every one and a half hours. No eldepryl. A fellow PD suggested taking sinemet witih orange juice - and it works. SOmetimes as much as two and a half hours go by and I realise I have forgotten my dose. More important than the amount of medicine I take, its when and how I eat the protein that really makes the most difference. Ithink I have played all possible games witih evey variation of times and quantites of sinemet. The other important thing is that I take medication right throgh the night. If I have too long a gap between doses or if I sleep 3 or 4 hours, then I crash down and at the other end have tremendous dyskinesia. So my alarm is set for every two hours - tho since I have been on the meripax, I seldom sleep that long at one go anyway. Hope this helps you. If you have any questions, I can try and help you based on my own experience. But a doctor I'm not! Hilary Blue (49/16) --------------------------------------------------------------------- Mark F. Hardy wrote: > > Help - I'm having severe 'down times' and am looking for ANY suggestions or > ideas. I was taking 1 sinemet 25/100 about every 1 to 1 1/2 hours, .5 mg of > Permax 3 times a day, one 5 mg Eldepryl, plus a vitamin C daily. > > I was starting to experience longer down times than I was used to - before, > I > could pop a 25/100 Sinemet and with-in 15-30 min's I was back to > functioning. > Then my nuerologist decided that maybe 50/200 Sinemet CR (time released) > would level out the down times, so he switched me to CR, plus I upped the > Permax from .5 to .75 mg (still 3 times a day). At 1st, it wasn't so bad, > but then > I noticed that when I 1st got up, the med's were taking longer to get me > going. > So, I called the nuero and convinced him to let me take (in addition) 1-2 > 25/100 > Sinemet 1st thing in the morning. That seemed to work, at least for getting > me > moving (unfrozen) 1st thing in the mornings. > > I ran out of the 25/100's and decided that I should REALLY try to get by > without > them. My down time (frozen) has continued to worsen, to the point now where > it > may take me 2-4 hours to get out of the frozen state - now, if I forget to > take my > med's, I can expect a longggg down time. This sudden drastic change is > scaring > me - am I doing something wrong, has my PD taken a turn for the worse, or > what? > > What else is different? I just had disc surgery and can't sit for 6 weeks. > No med's, > just have to take it easy. > > HELP - mark