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I've had an experience which I need your help to explain. I was diagnosed with PD (the rigidity type) ~ 6 yrs ago, and now take 6 Sinemet 10/100 tablets & 4 Sinemet 25/100 CR throughout the day, plus one or both early am if necessary. I do have rather severe end-dose "offs", no dyskenesias; mornings are my best time. A few months ago, a doctor who was studying people with PD & migraine asked if I would see her late a.m. without having taken any meds. I agreed, & did so. Then, a couple weeks ago, I saw a movement disorder physician at Mayo, late morning. I had taken morning meds, but was due for a 10/100 while there, which I didn't take. In both cases, I did very well, indeed! So much so that I seemed essentially normal during each appointment. I know that stress can definitely make PD symptoms worse. Can this work in the opposite way? Being with both of the doctors I mentioned was a very positive experience for me. Have any of you improved at times which are emotionally very good for you? A friend who was with me at Mayo has (I believe) misunderstood & now is rather convinced that I don't have PD. Discussions with her are now causing me quite a bit of stress! If you have had improvements when life is good, would you send me a note on this which I could show her? Or if you could share some neurochemistry information on this, that would really help a lot, too. She & I are both studiers. This is more important to me than I can express in this post, & I'll be very grateful for whatever you would be willing to contribute. M.Dawn 56/6