Hi Well 1) If PD is a lack of dopamine in the brain ??? 2) If drugs can be delivered via the nose avoiding the blood/brain barrier ??? It follows that the best treatement for PD is snorting dopamine !! I dont have a source of dopamine . But I tried snorting my L-dopa first thing this morning . I was hoping for a faster response . NO such luck . In fact it was far less than the normal swallowing . It would seem that the nasal delivery of drugs to the brain is drug and/or patient dependent . I am still wondering about snorting dopamine itself . Also I am not exactly clear why the blood brain barrier is avoided as I thought that that snorting was just a way of delivering drugs to the blood in the head rather than to the blood in the body . This is what made snorting a faster delivery of drugs to the brain . > LONDON (September 2, 1998 2:31 p.m. EDT http://www.nandotimes.com) - Nose > drops could transform the treatment of Alzheimer's disease and other illnesses > that waste away the brain, New Scientist magazine reported Wednesday, citing > recent research by a neuroscientist in Minnesota. > > The magazine said that the nasal passage, which provides a direct link to the > brain, could be the ideal conduit for delivering therapeutic drugs that cannot > reach the brain through the blood. > > The molecules of many drugs are so large they cannot cross the blood-brain > barrier -- cells in the blood vessels in and around the brain that form a kind > of barrier to guard brain tissue. > > Finding an effective method of delivering drugs directly to the brain has been > a stumbling block in treating neurological diseases. > > The neuroscientist, William Frey of the Alzheimer's Research Center at the > Regions Hospital in St. Paul, Minn., thought nose drops could be an ideal way > to get a new treatment for the disease into the brain. > > "I knew that bad things could get in this way. It occurred to me that maybe > good things could get in this way too," he said. > > He and his colleagues tested the theory on 12 rats. Half were given the > treatment in nose drops and the rest in an injection. Within an hour of > treatment Frey found that the treatment given in nose drops had reached the > hippocampus, amygdala and other regions of the rats' brains not involved in > smelling. > > In contrast, the rats that received injections had very little of the > treatment in their brains. "The nose, they say, could deliver drugs not only > for Alzheimer's disease but for a range of other neuro-degenerative conditions > as well, including Parkinson's disease and multiple sclerosis," the weekly > magazine said. > > Frey's team also used nose drops to administer insulin growth factor 1, a > treatment for strokes, and found similar results. They will report their > findings at a meeting of the American Association of Pharmaceutical Scientists > in San Francisco in November. > > Copyright 1998 Nando.net > Copyright 1998 Reuters News Service > > a new voice: http://www.newcountry.nu/pd/members/janet/index.htm > 51/10 - almonte/ontario/canada - [log in to unmask] > janet paterson > > peace Alastair ( [log in to unmask] )