 |
 |
Alastair Wyse wrote: > > Hi > > Well > 1) If PD is a lack of dopamine in the brain ??? > 2) If drugs can be delivered via the nose avoiding the blood/brain > barrier ??? > It follows that the best treatement for PD is snorting dopamine !! In general, drugs must pass TWO obstacles to reach the brain. You mentioned the blood-brain barrier, but there is also the problem of getting the drug into the blood. Drugs taken orally reach the blood through specialized cells in the walls of the gastrointestinal system (including mouth lining and tongue). When that's undesirable (for example, apomorphine p.o. makes you vomit) they try the injection or nasal lining route. In a trial of apomorpohine, some of the nasal subjects had to drop out because their lining got too irritated. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013