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Oh what a beautiful morning.... I just overturned a whole can of coke on my bed. Yes, I know, Ivan, it should have been orange juice, but I was too tired to go down to the kitchen - and just one time etc... Anyway coke is easier to clean from the mattress and yes I know, water would have been easier still. The point is, I've been doing every wrong the last couple of days, and my pill schedule has gone crazy. I feel I need more and more medicaition to achieve the same result. My kids could tell you straight away what the problem is - Mom's PMS-ing! Other YOP females that I hve spoken to have reported similar symptoms - mainly the seeeming change in the requirement for sinemet, which I g ess can be extrapolated to mean dopamine, Has any one carried out any sort of research into this topic? I mean serious, NIH kind of research?? Hilary Blue