Hi Joao > Hi Alastair , > > Alastair Wyse wrote: > > > 1) If PD is a lack of dopamine in the brain ??? > > 2) If drugs can be delivered via the nose avoiding the blood/brain > > barrier ??? > > It follows that the best treatement for PD is snorting dopamine !! > > I dont have a source of dopamine . But I tried snorting my L-dopa > > first thing this morning . I was hoping for a faster response . > > > > NO such luck . In fact it was far less than the normal swallowing . > > How did you proceed to inhale the levodopa ? Was it in a solid state ? Perhaps it > should be vaporized first to make it possible the snorting way . Or else powered to > a very fine state .... > I just emptied the powder out of my Madopar 125 cap and snorted it . I actually used the contents of two caps to allow for losses . Certainly the experiment could have been inproved . As you suggest I could have disolved the caps contents and either sprayed it or nose dropped it up my nose . This would have been a refinement I would have tried if the first crude trial had showed any positive results . Theoretically even if you do not accept the idea that snorting avoids the blood/brain barrier you should be getting a lot of delivery improvement by avoiding losses due to gut and liver . Assuming the drug is disolving in the nasal mucus and passing into the blood on the way to the brain it should avoid a lot of the chemicals used by the body to neutralise the drug ( In the case of L-dopa , com T) . I dont understand how this delivery system works and I suspect no one else does as there is no explanation . It may only work for certain types of drugs . I note that it works for IGF-1 . This drug is used to stimulate nerve regrowth and it is one of the drugs I intend to try this winter on a trip to Mexico (medical drugs are available over the counter without prescription ) , to see if it improves PD . I have got to wait till winter as I can no longer stand hot weather with PD . I still think snorting dopamine should be tried . Snorting nicotine in the form of snuff has been a traditional way of enhansing the brain's dopamine level as has snorting cocaine . I find in my case that boosting the dopamine level produces merely a feeling of light headeness ( ones first cigarette ) but no improvement in PD symptoms . L-dopa did nothing for me for 9 months . I was only after a week of 12 caps a day that I got any real benefit it unfortunately also increased my dyskinesia . Since then the beneficial effects of L-dopa are getting shorter and the dyskinesia worse . For these reasons I have serious doubts about PD being a shortage of dopamine . L-dopa does a lot more than boost the dopamine level . It seems to me that in my case these are the major therapeutic effects . Since PD theory is so inadequate to explain what I have experienced I feel one should have a stab at less conventional theories and practices to see if they work . It seems that conventional therapy leads to the the conventional result ( progressive worsening of symptoms ) . Snorting the contents of my Madopar cap was a small experiment . I have much bigger ones lined up . > > peace Alastair ( [log in to unmask] )