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Dear Joan Snyder - I am having a very different experience with Permax. I was dx in 1994 and have been on Permax for about a year now. I take 4-5 half Sinemet tablets (25/100) each day and 3 half permax (1 mg) each day. Granted, the Permax is very low dosage but it has been very helpful to me. I have been able to reduce my Sinemet a little and my restless leg problems at night have disappeared and I am sleeping much better. Nancy Shlaes deGrazia (61/4) I like your signature signoff. I don't have much patience with "try" either