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How right you are I have been on Sinamet cr 250mgs three times a day. I have an appoinment next week with my neurologist and will ask him to put me back on Madopar. I wa smuch better off takinfg smaller doses more frequently than I am with Sinamet. Will let you all know the outcome. Bernard from Austria. http://www.newcountry.nu/mag/shaw.htm