Helen, My father suffered with itchy skin for some years, starting well before he began showing neurological problems. The GP and dermatologist were unable to help. He experimented with different bath soaps and lotions, and my mother took extra care to use non-irritating detergents and to rinse the laundry twice. Since he began having neurological problems, the itching has been less bothersome. He is not on any medications, since they don't seem to help. He also has some swelling in the affected arm and ankles/feet, but we (doctors and I) are guessing that this is from a lack of exercise and from letting his nearly useless arm just hang down. This may not be of any help to you, but it's interesting that you suffer with unexplained itchiness, too. Also, since my Dad's problem is not associated with medications, it may suggest that yours is not, also. I hope you can solve it. It must be very irritating and frustrating! Jane K. (daughter of Fred, 80/1-MSA?)