Hi Edward, In response to your request for information about medica= tions, I thought it might help to let you know how I deal with Parkinsons= (I have had it for ten years now, not as long as some, but long enough = to have learnt something about drug regimes) Firstly, in my experience, the more Levadopa (Sinemet, or Madopar) that = you take in a day the less effective it becomes. For example, my first = dose of Madopar a day will give me benefit for upto 3 hours, my second = for upto 2 hours, and my third upto 1 and a half hours. This also has = an effect on the next days effectiveness, for example if for some reason = I only take two doses of madopar in a day, the following days first dose = may last up to 3and a half,maybe four hours however,If for some reason = I need to take four doses of Madopar in a day, then the next mornings fir= st dose may well only last 1 and a half to 2 hours.It is a case of fine = tuning your meds regime to get the optimum benefit with the minimum of = down time.No regime is going to be perfect,because the inescapeable fact = is we all have Parkinsons, but it is possible to manage the symptoms effe= ctively. I also note from your message that you take Eldepryl at midday, this goes= against what my Neuro' told me, and my own experience, which is that it = should only be taken in the morning as it can cause sleeplessness if take= n later. I feel better now than I have for a long time, which is mainly due to the= fact that I feel I have found the optimum dosage . Regards, Regards, Nigel, Age 43, diagnosed 1989, Taking Madopar, Cabaser, Selegeline, Amantadine, Amitriptyline. [log in to unmask]