Hi Gerry & Brig: Doctor has taken me off the Permax and started me on Mirapex. It has been 4 days now since being on Mirapex and my legs look like chopped liver. They are a bright red still, very dry, skin shiny and stretched until no stretch left. There is no give in the skin. The dimples in my knees are gone, there really is not knee cap to see. Bending down or kneeling are out of the question. At the end of the day, the legs are like walking on stubs. They are hot to the touch, but then all of a sudden the feet and toes turn cold. I have been in contact with the doctor in Chicago and first was reduction of Permax (did not help), second was phase out Permax, phase in Mirapex. Mirapex is doing what it should for PD, but the legs/ankles/feet are still a mess, worse then before. All I know, is that I am very tired of trying to walk at all now. It is a nightmare that is beginning to have no end. I trust the doctors now and believe they have my best interest at heart. I am researching the other meds in the realm to see if maybe one of them may be causing some problems. Lithium I have taken for about 8 years now, but some of this sounds like Lithium overdose. Patience is wearing off, as well as tolerance. The Acceptance part is lost in the corner as the problems crop up. Since I have never been treated for PD and don't know the ins and outs, if you have had similar problems, could you please let me know if they were med related due to PD or some other med. Or was it PD itself? I usually am a Half-Full type person but I am getting very tired. I don't sleep, my legs are horrible, being chased by Hallucinations, being Paranoid by anything, No transportation, tremors, head bobbing, etc. I am tired and worn out, needing a good word, to be pushed up the ladder one more time. To at least see the leg thing through. And continue this battle for the next hurdle to come. But by morning I will probably be back to my normal talkative self. I am curious as to if many of Parkies know what brought PD on them? Or if you just have a hunch? Are you still hopeful of a cure? How long did your meds take to straighten out so they worked and gave the least amount of side effects? Is your doctor local or did you have to go to another town to get good medical care? What side effects did you have when you started? What were the symptoms? I really haven't asked much because I didn't want to appear stupid. I don't believe anyone is stupid, we just lack knowledge. If you have any other information for me that may help, please post to me. I am searching for answers that are coming very slowly or sometimes not at all. I need personal knowledge. Thank you for your answers, I am scrambling to stop the legs. TTFN Gina