Janet Paterson put the sinemet story very clearly and others
(Ken and Joe and?) also answered
but I typed an answer too
So here's my 2 cents
someone asked why all the different sizes of Sinemet
There is some thought behind all those sizes
this is how they stack up in Canada
*check with your doctor and pharmacist*
A the regular sinemet (blue) 10/100 and 25/250 both are quickly
absorbed
and ready to be used
they have carbidopa in a 10-100 ratio with the levodopa
about 90% of the levodopa is bioavailable
B the regular sinemet (yellow) 25/100 quickly absorbed and ready to
be used
has carbidopa in a 25-100 ratio which is preferred by some
who want too be sure of enough carbidopa
about 90% of the levodopa is bioavailable
C CR= controlled release, there are two sizes I'm not sure of the
exact proportions
the larger is scored and may be broken in two, the smaller should
not be broken
CR has a coating which makes the tablet dissolve slowly thus the
levodopa is
available for a longer time
CR should not be chewed or crushed
about 70% of the levodopa is bioavailable
anne ruherford
