Hi Helen 'n Dad <smile>.... I often can get another 3/4 of an hour or even a bit more "on time" shortly before I'm due to take my next dose (I take Sinemet only and have had PD 23 years) if I eat something sweet. "Sweet," can be a glass of O.J., or a few teaspoons of ice cream, or a coupla cookies. I was unconsciously extending my "on" time like this for about a year until one day it dawned on me what I'd been doing. At that point I made a point of observing how my eating habits affected my PD, and while I cannot speak for other Parkies, I've been able to often-but-not-always manipulate how I feel and how I respond to my meds by controlling what and when I eat. Mind you, this is a MODEST manipulation of my diet... a small manipulation, NOT a major one. But that I get a very positive response - both physically AND emotionally (in a "Score one for ME against PD" kinda "up" feeling) each time I nibble or sip a sweet food or beverage and extend my "on" time. SOOOO.... Dad, your'e right-on! Barb Mallut [log in to unmask] rkinson's Information Exchange on behalf of Helen Griffiths Sent: Saturday, October 03, 1998 1:27 PM To: Multiple recipients of list PARKINSN Subject: Feeling Good When Medication's Low? My father takes Mirapex & Sinamet. Like many of you, he is struggling to get the combination of medications, doseages, and times of doseages that will best reduce his symptoms. Recently the neuro has been increasing his Mirapex. (Sorry, don't have dose at hand). He seems to tolerate the increase OK but we're not sure if there's been much improvement either. He has however noticed something interesting. Some days, when he gets up after a meal, before taking his next pills, he is in unexpectedly great shape. Moves with ease etc. Says it feels wonderful. Unfortunately it doesn't last long and it doesn't happen all the time. The strange thing is this happens about 4 hours after his medications. ...Sometimes on the way to get a glass of water for his next pills. Is there anyone who can relate to this or has some insight? I know my father will look forward to the stack of your printed replies that I will take over when I visit next. Thankyou from both of us! Helen -- Helen [log in to unmask]