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Hello William and Pete I have had Parkinson 15 years and also take Sinemet Cr., regular Sinemet, Amantadine and Mirapex. I wake up in the morning, not having any problems moving but all knotted up in my loweer back and have trouble putting any weight on my feet. It is like cramps. Has anybody heard that Sinemet Cr. causes pain of any kind? Marianne Rome -----Original Message----- From: Pete DeFord <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Date: Monday, October 12, 1998 6:30 PM Subject: Re: Sinemet >Good evening William, > I too, take sinemetCR/ 50/200. I take 8crs+.5 mirapex 3v times a >day+50mgs. of tasmar 3 times a day+ ,5 of cogentin twice a day. I also take >reg. sinemet 25/100 as needed to "jumpstart" CRs.(I use as little as 1/8 of >the 25/100. > I take only thecrs at night. If i don't take enough sinemet i can't turn >over. And i would be so rigid in the morning it would take me at leasf 1/2 a >day to loosen up. > You mentioned i assume a blood level for dopamine and leva-dopa. How do >we obtain a measurement of these levels? How do we know what level of >dopamine and leva -dopa we need to maintain? > Also,do you have any difficulties with dyskinesia? >You also mentioned musxcle cramping-I have dystonic type pain in my right leg >and my right shoulder--had a pallikdotomty in 1998--diag. in 1982 > >any info-you can share would be appreciated.--pete >