Dear Hilary, Ida, Ivan, et al, Hilary, your early experience with amantadine somewhat parallels mine as it was one of the early ones tried on me--not only didn't seem to work but seemed to make it worse, I thought. :Last December I was in the first human trials for Remacemide which is considered a glutamate antagonist which will block the glutamate effect and thereby enhance the levodopa effect. I've heard it referred to as potentially equivalent to a "non-surgical pallidotemy." Our assessment of its effect on me was quite positive, and I was sorry when the study was over. My MDS at the time and since has recommended that I try Amantadine (my earlier experience with it was prior to my becoming a patient at KUMC). because it is the closest drug now available on the market to Remacemide. Just in the past month, I have thought maybe I should give Amantadine (aka Symmetrel) another try. Now with the recent postings by you, Ida, in explaining the properties of amantadine; and what your short-term recent experience has been, Hilary, I am really re-considering giving it a retry. I sure hope it continues to help you, Hilary. Barbara Blake-Krebs 58/14 Merriam KS [log in to unmask] on 10/10/98 Hilary wrote in part: << Ten days ago, I asked Dr Sigmund if I could try taking amantadine again. I had read on the list that some pwps were having a fair amount of success with it. And she said why not? and - I guess it was the amantadine - its been like a miracle. As long as I take my meds on time, I have hardly any symptoms of PD >>