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In a message dated 10/10/98 3:11:22 PM Central Daylight Time, [log in to unmask] writes: << I take sinemet and permax at night. Ihave done so for at least 3 years. I began as a way to avoid very slow and miserable mornings. My Dr was doubtful but said I could try. The dose was not increased just divided into eight doses instead of six. Ihave had Parkinsons 18 years.So far no vivid dreams and no mental problems (touch wood ) I try to get by on as little med as possible while being able to function fairly well but it is getting hard to manage. Anne Rutherford 64 24 18 >> In a message dated 10/10/98 4:08:09 PM Central Daylight Time, [log in to unmask] writes: << trouble so I wont go into numbers of pills. I take sinemet and permax at night. Ihave done so for at least 3 years. I began as a way to avoid very slow and miserable mornings. >> Hillary, I swiped someone's piece above and am sending it. It illustrates the fact that we are all different. However, not every smoker gets lung cancer either. This is difficult because I have no study or other data to quote to you. I'm sorry but we are packing to deliver stuff to neighbors and others and I am sleepy (hte Clozaril is kicking in). Concerning he practice of talking round the clock doses of sinemet.: One does better by going through the night without taking more Sinemet. This will not be any well-documented treatise. My points are these : 1. I take my prejudice against it starting back when Alan Bonander (someone whose opinion I valued) advised Pat Schark against doing so. 2. I believe I have found the days following nocturnal doses to be more dyskinetic. 3. In the long term, I think the general agreement is that nocturnal dosing leads to shorter interval between doses, sooner. All I can add from experience is that I didn't like the next days on time. Being off in the morning for me often. leads to great afternoons . Regards, WHH 55/19