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Veels danke. Thank you, Ida Thanks for the (as usual) crystal clear explanation of how amantadine works. YOu have the gift of making something very complex seem simple and straight forward - a wonderful talent, especially in a language not your mother tongue. Ek bedank u. Hilary Blue P.S. Ek is in Suid Afrika gebore, en kan Afrikaans praat. Ek is seker u kan dit goed verstaan. Veels beter as wat ek Nederlands kan verstaan! -------------------------------------------------------------------------------------------------------------- Ida & Andre Kamphuis wrote: > > Now Ida, do I have this correctly? -- Amantadine IS in fact an antiviral > >medication, but, its effectiveness in reducing tremor in PD is because it > >is ALSO a glutamate antagonist, and glutamates inhibit dopamine. > > Ivan > > That is not completely correct. Amantadine started its career as a med, > against virusses. > It was discovered by coincidence. I guess a PWP suffered from the flue, > that it amelioreated > too PD. But why it could do so was for a long time a mystery. I don't know > how and when it > is discovered to be an anti-glutamate too. But it seems to be (so they Say). > > But there is more. Researchers do know much of the role of glutamate. To > understand this > one has first to know that in the CNS much systens are managed by two > transmitters(who are > antagonist in relation to each other and are mutual inhibiting. .......... > Another partner of dopamine is glutamate. They both manage the level of > activity in > .o.the Globus Pallidus. So in PWP,s the glutamates are too active in the > Globus Pallidus, > and that caueses a too high level of motor activity, which cannot be > inhibited. > Regards IDA >