---------- From: William T.Wallace Jr.[SMTP:[log in to unmask]] Sinemet I am a new observer /reader of your PD network. I am a parkinsonian, = diagnosed in 1986. I am 63 years old and retired from state public = health positions last year. I am interested in the discussions about Sinemet use at night. I = attempt to maintain a 24 hour level of dopamine and Permax. I use both = the Sinemet CR - 25/100 q4h.The Permax I also take q4h I have spent long = hours attempting to maintain a perfect balance (impossible as you know). = If that is not enough, I supplement with short acting Sinemet. All = this works quite well for me.My goal is to prevent leg cramps which = plagued me for a couple of years. It seems to work. It never keeps me = awake. I am asleep shortly after my head hits the pillow. I will attempt = to answer any questions William T. Wallace MD, MPH