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Still a relative newbie (54/2 and learning), I find taking levodopa at bedtime helps ... it alleviates late night (I'm a night owl) RLS, and like Brian Collins, since adding a late dose I mostly get a good 6+ hours of unbroken sleep. Best of all, I no longer need to visit the loo during the night ... still remember my amazement the first time in years I woke at about 7 am and realised I'd slept undisturbed right through the night). I take a minimal dose (Madopar, 1 x 50/12.5 roughly x 3 hrly from 6 am to 6 pm, then 1 again about midnight). When this no longer works for me, I think I'd like to try adding Amantadine again before branching out onto anything different ... it worked brilliantly for me before, if only for a short while until I developed intolerable side effects (peripheral oedema, constipation, metallic taste and loss of appetite, blotchy skin). I'd like to try taking, say, half the previous dose to see if I can get symptomatic relief without what felt then like some kind of toxic overload. For what it's worth ... Beth Leslie Fremantle, W. Australia