Good evening William, I too, take sinemetCR/ 50/200. I take 8crs+.5 mirapex 3v times a day+50mgs. of tasmar 3 times a day+ ,5 of cogentin twice a day. I also take reg. sinemet 25/100 as needed to "jumpstart" CRs.(I use as little as 1/8 of the 25/100. I take only thecrs at night. If i don't take enough sinemet i can't turn over. And i would be so rigid in the morning it would take me at leasf 1/2 a day to loosen up. You mentioned i assume a blood level for dopamine and leva-dopa. How do we obtain a measurement of these levels? How do we know what level of dopamine and leva -dopa we need to maintain? Also,do you have any difficulties with dyskinesia? You also mentioned musxcle cramping-I have dystonic type pain in my right leg and my right shoulder--had a pallikdotomty in 1998--diag. in 1982 any info-you can share would be appreciated.--pete