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On Mon 12 Oct, Marty Rose wrote: > Can anyone tell me if Permax causes increased dyskinesia like Mirapex does? > I never got to a very high dosage of Permax and I am now at nearly 4 mg per day of Mir > apex and it is giving me fits. My dyskinesia is really getting bad. Any thoughts wo > uld be appreciated. > > Marty Rose 58/10 > [log in to unmask] > Hello Marty, Are you still taking any Sinemet? If the answer is Yes, then cut down on the Sinemet. If the manufacturers are to be believed, neither Permax or Mirapex cause dyskinesia. I can vouch for the Permax, but I have not tried Mirapex myself. I am prepared to believe the claims however, because ALL of the recent crop of Dopamine Agonists seem to work. That is; they all provide more operating margin, without provoking dyskinesias. The differences between the various agonists come to the fore when we start looking at side-effects. each make of tablet is different in its side-effects, and each PWP reacts differently to the agonists. Side effects are not your problem however. If you are taking Sinemet, the remedy is obvious; take less. If you are not taking Sinemet, then as they say 'Houston- we have a problem! Regards -- Brian Collins <[log in to unmask]>