Hello, I take mirapex(began in Nov, 1997) and sinemet (began in 1984)-I was put on mirapex to bring sinemet dosage down as unlike sinemet which my body has to deal with a sensitivity to protein with the levadopa that is not present with mirapex. I do at times hhave problems with dysk. My main decision has been since i hav e added tasmar how much and when to take meds. in order to minimize to effects of OFF TIME(ALSO CALLED BRADYKINESIC EPISODES). i am still working on that. Best of luck to you----pete