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Nigel In theory Tolcapone [TASMAR] should reduce nausea since it decreases the amount of levodopa required. It performs a function quite like carbidopa in Sinemet. I take entacapone [COMTESS] which has the same function as tolcapone. I have no nausea. "In theory" means that what happens shouldn't but it does anyway. Some others have reported some nausea. More have reported diarrhea which in a mild form benefits PD patients who have constipation problems. Will Johnnston A.P.D.A. DelMarVA Chapter Pres. 4049 Oakland School Road Salisbury MD 21804 USA 410-543-0110 ---------- From: N Cockle <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Subject: Tolcapone and nausea Date: Tuesday, October 20, 1998 12:09 PM Hello Everyone: I have a friend who has tried Tolcapone, it has been helpful to reduce Sinemet, however, it causes nausea and feeling flu like. Is this something that passes or are there ways to take Tolcapone with anything else to reduce unwanted side effects. The amount taken is just 100 mg three times daily. Would appreciate any advice or experiences. Thanks.........Nigel ------------------------------------------------- Nigel Cockle 59 Norley Road, Cuddington, Northwich, Cheshire. CW8 2JY England Tel +44 1606 882150 Email [log in to unmask] -------------------------------------------------