Hi Marty: I tried sending you a response on effects from mirapex and permax,and you probably did not receive it so seeing your name again I will try again. I mentioned a friend who found that he had a very bad first day on mirapex, but things got much better when he cut down on the Sinemet. No further problems with dyskinesia, and he has really liked what mirapex has done for him. I have had good results with permax, but dyskinesia was getting out of hand prior to getting a DBS device on both sides. Best Wisshes, Bill > age 60/dx 1990