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Dear William, Your statement seems to fit my Mother's more closely than any I've read about so far. Leg cramps were the only real physical pain she has experienced and that only when in tremor. Since we have that fairly well controlled (since April this year) , her legs have not bothered her at all, the first time in many years. She takes no CR, just the fast acting in two different strengths, 3 times a day which she took for years. (1 - 25/250 in AM, half 25/250 and half 10/100 at noon and dinner. The miracle is when Seroquel was added to help with hallucinations and it worked as an agonist (sp?) for her, also. The doctors have been very surprised at that reaction. I find myself "waiting for the other shoe to drop" while trying to stay positive at the same time. :) Sharon Starr, daughter and caregiver to Rae 74/50/45 (age now / age diag / age first symptom, ie. trembling little finger) [log in to unmask] -----Original Message----- From: William T.Wallace Jr. <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Date: Sunday, October 11, 1998 7:38 PM Subject: Re: Sinemet >---------- >From: William T.Wallace Jr.[SMTP:[log in to unmask]] >Sinemet > >I am a new observer /reader of your PD network. I am a parkinsonian, diagnosed in 1986. I am 63 years old and retired from state public health >positions last year. > I am interested in the discussions about Sinemet use at night. I attempt to maintain a 24 hour level of dopamine and Permax. I use both the Sinemet CR - 25/100 q4h.The Permax I also take q4h I have spent long hours attempting to maintain a perfect balance (impossible as you know). If that is not enough, I supplement with short acting Sinemet. All this works quite well for me.My goal is to prevent leg cramps which plagued me for a couple of years. It seems to work. It never keeps me awake. I am asleep shortly after my head hits the pillow. I will attempt to answer any questions > William T. Wallace MD, MPH >