Yup, I have sweating and cold extremities too. I am a recent diagnosis PWP and so am on Amantadine 100 2 times a day and Eldepryl 5 mg every morning. I feel a flush in the am after 1 hour when taking the meds. Also, occasionally one hour after the evening dose of Amantadine. I always have cold feet and hand, especially in cold weather and when the Air Cond is a bit coolish at a location. I have sweat profusely twice with an all body drenching, but that was pre-label of PWP. Now occasionally I sweat profusely mainly from the head, back of neck and behind the ears. Like a faucet! Boy, the "wonders" of this body never cease to amaze me! By the way, being on antiobiotics moderates all these symptoms Why? Good research question that I would love to investigate! Also, information and a question I started taking Evening Primose Oil, Glutathione, and Vit B 12 as was suggested in an early Oct or late Sept listserv message. So far (3 weeks) I have noticed no negative side effects but am tickled to report that my energy level has increased. Don't know if that is all related, but will let you know. Anyone else just starting out on these supplements notice any differences? So far, for me, the protective properties and the effect of the supplements have me pleased. FYI Karen (53/symptoms: +10/ diag: 6mos)