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What kind of adverse reactions are you talking about? I haven'e heard anything about that. Marty mrose @sirus.com -----Original Message----- From: Bruce Warr <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Date: Sunday, November 08, 1998 10:05 PM Subject: Tasmar Works for Me >I saw my neurologist a week and a half ago. I requested that I try Tasmar >and he agreed. My total "ON" time during the day was about six hours with >noticeable dyskinesia during about two of those hours. My meds at that time >were Sinemet 25/250 1 tab qid, Sinemet CR 50/200 2 tabs qid, and Mirapex 1mg >1-1/2 tab tid. > >I started out the Tasmar with one 100mg tab tid. I was so dyskinetic I >could have been on Soul Train. I cut back on my Sinemet CR by 1/2 tab qid. >Dyskinesia disappeared and total "on" time increased to about 10 hours, but >there was a sudden change from "on" to "off". So I increased the Tasmar to >one 200mg tab tid. Dyskinesia came back but daytime "off" periods were >almost eliminated. > >Today I waited to take my second dose of the day until the first wore off. >Following is a record of events: > >0830 Took 1st dose >0900 Began coming "on". >0930 completely "on". > NOTE: this was probably the Sinemet 25/250. >1130 Dyskinesia begins. > NOTE: probably the Sinemet CR 50/200. >1530 Dyskinesia disappears. >1630 Wearing off begins (relatively slow> I can still type this message). > >I am going to reduce the Sinemet CR to 1 tab qid and then adjust the timing >of the doses. If I can get it right, it looks like my "off" times will be >significantly reduced by the use of Tasmar. (And yes, I am aware of the >studies that indicate Tasmar may have an adverse effect farther down the >road.) > > >Bruce >57/10 >Sinemet, Mirapex & Tasmar