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In a message dated 11/11/98 6:51:52 AM Central Standard Time, [log in to unmask] writes: << Is there anybody using NADH? Is it effective? >> In a message dated 11/11/98 6:51:52 AM Central Standard Time, [log in to unmask] writes: << Is there anybody using NADH? Is it effective? >> Mr. Paolini, I have been using NADH for about two years now. I take one 2.5 mg tablet one hour before starting my regular drugs (Mirapex Sinemet Dreprenyl and Amantadine). I used it previously for about one year, stopping when I could find no doctor in the US willing to learn about it. Both times, it was effective in smoothing out the fluctuations in Sinemet effects. I do not use it as Dr Birkmayer would have me do it. He wants it used to "replace the L-dopa drugs" and I use it as an adjunct (extra) drug. Its effects are good and I can reduce my Sinemet (L-dopa) intake while taking it, but when I turn off at night, I am more rigid than before. I still do no know whether it is safe to do what I am doing., but it has improved my life (more on time, and fewer dyskinesias once I cut back on the Sinemet) a lot. Regards, WHH