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I'm starting to wonder about Tasmar. As I understand it, what Tasmar does is reduce the intake requirement for levodopa and allegedly smooth out levodopa's delivery to the brain by opposing the breakdown of levodopa in the bloodstream. This occurs outside the brain. When the proper but rather tricky to achieve Tasmar + reduced levodopa balance is arrived at, the brain receives the same amount of levodopa as it previously got from levodopa alone. Perhaps that's an improvement if levodopa bothers your stomach. But can't the same results in terms of dopamine production be achieved with sinemet CR supplemented with bits of regular sinemet when a quicker response is needed to fill in some gaps? I'm trying to think back on how it was before Tasmar, and things seemed simpler, perhaps better. But I didn't keep records and I don't trust my memory. I must ask my neuro about this next time I see him. Phil Tompkins Hoboken NJ age 60/dx 1990