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J. R. Bruman wrote: > 1. Since you don't want dyskinesia from too much levodopa at one > time, ... if you need a lot you must take it in small frequent > doses.... What Tasmar does is greatly prolong the retention of > levodopa so you need not take it so often. With Tasmar I seem to have even more trouble than before achieving the proper level of levodopa. They don't package sinemet (straight or CR) in pills of the optimum "denominations" for use all by itself, not mention use in conjunction with several other drugs like a COMT inhibitor, an MAOB inhibitor and a dopamine agonist. And these all have different effective durations. So after starting the day with dose 1 of everything, what and in what strength should you take next, and when should you take it? And then what do you take after that? Not that I'm trying to determine all this and act accordingly, but one would have to, taking meals into account as well, in order to maintain the optimum proportions. There are just too many variables to juggle, especially as PD advances and that fateful "therapeutic window" (the difference between a dose that is too small and one that is too great) is closing. So I now get dyskinesia without taking a lot of l-dopa, and, for some reason, I don't know whether because of advancing PD or the drug mix, for me the margin between too much and too little sinemet seems even narrower. BTW I appreciate your comments, Joe. Phil Tompkins Hoboken NJ age 60/dx 1990