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I'm forwarding the following information I received from WE-MOVE (Worldwide Education and Awareness for Movement Disorders). Does anyone have more information on genetic links between PD and essential tremor? Linda Herman --------- Forwarded message ---------- From: WE MOVE <[log in to unmask]> To: [log in to unmask] Date: Thu, 12 Nov 1998 10:43:46 -0700 Subject: Genetic Link between PD and ET Message-ID: <[log in to unmask]> 4p haplotype segregating with familial Lewy body parkinsonism MJ Farrer, K Gwinn, MD Muenter, F Wavrant DeVrieze, R Crook, J Perez-Tur, S Lincoln, DM Maraganore, C Adler, S Newman, K MacElwee, P McCarthy, C Miller, C Waters, JA Hardy Movement Disorders 1998;13(suppl 2):253 (Abstract 4.154) Haplotype analysis of a family with both early-onset PD and essential tremor has established the first genetic link between the two disorders. The announcement was made in a special platform presentation at the 5th International Congress of Parkinson's Disease and Movement Disorders in New York City, extending the results reported in a poster presented by the authors. Of 175 identified family members over four generations, DNA analysis has been performed on 38. Of these, 6 have PD and 6 have ET. All 12 have the particular 4p haplotype, while no unaffecteds do. Inheritance appears to be autosomal dominant. ET has been found in children of parents with PD, but not the reverse as of yet. Candidate genes have not yet been identified. The team would like to hear of other PD/ET families, and can be contacted at [log in to unmask] Copyright 1998 WE MOVE Editor: Richard Robinson ([log in to unmask]) E-MOVE archives, plus information on subscribing and unsubscribing, are available at http://www.wemove.org/em_intro.html E-MOVE is a service of WE MOVE (Worldwide Education and Awareness for Movement Disorders) 204 West 84th Street New York, NY 10024 TEL 800-437-MOV2 TEL 212-241-8567 FAX 212-987-7363 http://www.wemove.org