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^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) Ivan Suzman 48/39/36 [log in to unmask] :-) Portland, Maine land of lighthouses 38 deg. F :-) ******************************************************************** Hi Dominic, I use Tasmar, with great success. My neurologist and I have me at 5 doses /day. These are 1 x 25 mg, and 4 x 50 mg. This total of 225 mg/day of Tasmar seems to work best for me.. A pill-cutter is used to slice 100 mg tablets. Your post raised 4 QUESTIONS , which I am hoping you might be able to answer for us, and any other interested Tasmar users. Thanks for a valuable addition to my bulging Tasmar file. Hope my questions are of wide usefulness to listmembers. They follow, interlaced with short extracts from your longer post to the list. -IVAN --On Sat, 14 Nov 1998 18:41:03 EST Dominic Marchese <[log in to unmask]> writes, in part: > I received information regarding Tasmar and have forwarded it below. QUESTION 1: Dominic, who provided us with the Tasmar information you kindly forwarded? Roche Co.? > Second, remember that dopamine is metabolized via two metabolic pathways. QUESTION 2: Are these pathways the tyrosine pathway in the substantia nigra, and the "adrenal" pathway? Can any listmember explain, simply, how these 2 pathways differ biochemically? > Inhibiting COM-T, in all probability, just results in an increase in MAO-B activity QUESTION 3 :Does this mean that Eldepryl and Tasmar do the same thing in the brain? If each one is an MAO-B inhibitor, in the brain, is Eldepryl unnecessary when taken with SInemet and Tasmar? > However, given the side effect issues that have surfaced over the past several months, I would try to keep the dosage levels at the 100mg TID level, and be very cautious about going higher. QUESTION 4: I use 225 mg/day. How did you arrive at this 100 mg/day level? Is body weight important? My body weight is 73kg/160 lbs. I wonder if one's individual weight, speed of digestion, or dose usage rate are factors to be considered in estimating a maximum Tasmar dose/day? Thanks again, Dominic,(and anyone else) for your comments on these 4 questions. Ivan