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> Next I started reading some abstracts of two sets of lectures on > drug release mechanisms given by European pharmacy professors who are > members of the Controlled Release Society, which I found at: > http://www.medfarm.unito.pharmaco/itcrs/erasmus/erasma.html given in > 1995 and http://www.unipr.it/arpa/dipfarm/erasmus/erasma.html I couldn't connect to either of these URLs, so can't give a good answer to your remaining questions. > There seem to be problems with solid CR dosages at certain points in > the cycle. I can't be sure what the prof. is referring to; however, slowed peristalsis is common in PD, and accounts for the increase in choking, heartburn/reflux, delayed stomach emptying, and constipation. It may be that this is what the professor was talking about. > Controlled release mechanisms of various forms are still being worked > on, and the solid dose form, represented by sinemet CR, may not be > the last word or the best delivery form. Until better forms appear, > I wonder whether there are times in the various phases of the > digestive and intradigestive processes when small frequent doses of > regular sinemet might be better than CR. Has anyone looked at this > possiblity? Yes, some neurologists recommend use of liquid Sinemet for certain people. > Or am I best off somehow adapting my food cycle to the > limitations of my pill cycle? That's a good question to take up with your neuro, and I recommend you ask for a referral to a registered dietitian who can help you track food-medication interactions. Best regards, Kathrynne -- Kathrynne Holden, MS, RD "Nutrition you can live with!" Medical nutrition therapy http://www.nutritionucanlivewith.com/ Tel: 970-493-6532 // Fax: 970-493-6538 "If we knew what it was we were doing, it would not be called research, would it?" -Albert Einstein