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i read, or I heard somewhere, the theory that aspartame, because it is a large molecule, acts in pretty much the same way as protein, and inhibits the uptake of sinemet. Does this sound feasible to you? Hilary Blue ----------------------------------------------------------------------- Kathrynne Holden, MS,RD wrote: > > Hi Martin, > I haven't found anything specific to PD with regard to adverse effects > of aspartame; however, here's a study that I think should stimulate > further research, at the very least. Because people with PD often > experience depression, I don't recommend aspartame use to my clients. > ============== > > Walton RG, Hudak R, and Green-Waite RJ. Adverse reactions to aspartame: > double-blind challenge in patients from a vulnerable population. Biol > Psychiatry 1993 Jul 1-15; 34(1-2): 13-7. > > This study was designed to ascertain whether individuals with mood > disorders > are particularly vulnerable to adverse effects of aspartame. Although > the > protocol required the recruitment of 40 patients with unipolar > depression and > a similar number of individuals without a psychiatric history, the > project was > halted by the Institutional Review Board after a total of 13 individuals > had > completed the study because of the severity of reactions within the > group of > patients with a history of depression. In a crossover design, subjects > received aspartame 30 mg/kg/day or placebo for 7 days. Despite the > small n, > there was a significant difference between aspartame and placebo in > number and > severity of symptoms for patients with a history of depression, whereas > for > individuals without such a history there was not. We conclude that > individuals with mood disorders are particularly sensitive to this > artificial > sweetener and its use in this population should be discouraged. > > Martin Bayne wrote: > > > > I'm usually pretty good at extracting research data on the Internet, but > > I'm frustrated with my efforts to learn if those with PD should avoid > > Nutrasweet. I read anecdotal accounts of aspartame as a "neurotoxin," > > but no research data to support the hyperbole. I would be grateful if > > someone in the group could point me in the right direction. Martin > > Bayne [log in to unmask] > > -- > Kathrynne Holden, MS, RD > "Nutrition you can live with!" > Medical nutrition therapy > http://www.nutritionucanlivewith.com/ > Tel: 970-493-6532 // Fax: 970-493-6538 > "If we knew what it was we were doing, > it would not be called research, > would it?" -Albert Einstein