Dear friends on the List Briefly....as your occasional commentator on what we all hear.....about tolcapone (Tasmar): I have scheduled an appointment with my neurologist, and will continue on Tasmar. I started on just 50 mg/ day ( 2 x 25) with IMMEDIATE improvement. 100 has always been too strong a dose for me. Using the pill cutter. Later restricted 1st dose to mid-morning, not pre-breakfast. After 9 months, still making wonderful improvement-increased many of my on-periods from 1.5 to 2 hours each, to 3 hours per on-period. Today had two consecutive 10-minute off periods linked to 2 smooth and comfortable 3-hour on-periods!!!! Best day imaginable. Now I use 25, 50,50,50 50 for a 225 mg daily total. My body weight is 73 kg. JRBruman argues that 3/60000 deaths could be explained by normal 3/60000 rate of viral attack on liver. So I am listening to my body, ever-watchful, and onwards with Tasmar. Plus it reduces intestinal blockage caused by PD and by Sinemet. Plus Sinemet only 800/24 hour day -had been 1600 Gerry Haines and Brig you are not alone. How about it folks? Is my secret that I only use a maximum of 50 mg per dose, so my exposure is more gradual.? I have been pushing for 25 mg and 50 mg tablets. Less risk!! Be kind to thy body it is a holy temple. Now for all this great PR, Roche should pay for a decent salary for my caregivers so that I am not endlessly exhausted trying to find underpaid caregivers at $6.25/hour. Roche you now owe me something MAJOR to stabilize my CG system. The politics of publicity. Ivan Suzman. Portland Maine USA 49 (today is my birthday)/39/36 reknowned PD advocate also known as Professor Ivan...... Power to the Parkinsonian People