Chris, Expect the unexpected. PD is technically not a disease, but a collection of symptoms which if they respond to Sinemet are attributed to low dopamine levels in the brain caused by a death of dopamine producing brain cells. Since it is not known why the cells die nor do we have a metric or accurate method for measuring death rate, it becomes rather difficult to predict the future any better than a coin toss. As Charlie pointed out, after long term (very nebulous at to what this means with PD) Sinemet use and disease progression, it becomes more difficult to meter the levadopa to alleviate symptoms. You either freeze from undermedication or have uncontrolled movement from over medication. The point at which all this occurs can happen three years from diagnosis or symptoms or twenty-five years from diagnosis or symptoms. There has been a lot of progress in just the two years since I was diagnosed so I am optimistic. Your hubby is on the right track since he is already exercising. Both tremor and dystonia are very fatiguing and the better his physical condition, the better he will be able to cope with the symptoms. He should get an appoinment with a physical therapist for an exercise regiment best suited to counter his symptoms. Improper use of weights can actually aggrevate symptoms. Fatigued muscles from PD eventually lead to poor posture and contribute to problems with balance. An exercise program which stresses stretching and extending endurance will be most beneficial. Just some more data points to help you deal with the uncertainty. Phil Gesotti 49/46 Peter Carras wrote: > I would appreciate some advice as to what to expect from my husband's > PD. He is 73 and has been on medication for six months. > > He has tremendous energy - like a 33 year old man- lifts weights- good > attitude - maintains and landscapes yard - and seems to be in good > spirits except for short periods of fatigue. > > It is hard to comprehend this is not going to continue - please advise. > > Thank you, > Chris