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welcome, Jimmy Dooher are you taking 25/100 Sinemet and 0.25 mg Mirapex three times a day together? there is likely to be more benefit in taking half as much twice as often. staggering the time you take the Mirapex from the times you take the Sinemet will also tend to level the amount of medication in your bloodstream. this is recommended. check with your doctor. -- Ron Vetter 1936, '84 PD dz [log in to unmask] http://www.ridgecrest.ca.us/~rfvetter