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the herb kava-kava has been implicated as detrimetal to parkinsonians.


Kava first piqued scientific interest during the mid-1800s, when
researchers traced kava's relaxing
properties to kavalactones, which are found in its root and relax
muscles without blocking nerve
signals that keep the muscles tense. This may explain how kava can relax
muscles without numbing
the thinking process. But kava's mind-altering action has largely been
ignored in modern times due
to the development of synthetic psychopharmaceuticals, including
antidepressants. Recently,
however, kava and other plant therapies have received more attention
because undesirable side
effects, including addiction, can make some synthetic drugs unsuitable
for long-term treatment.

What science says about kava
Kavalactones have been shown to relieve anxiety and pain and relax
muscles in laboratory animals.
In humans, they have been shown to change brain activity (as measured by
an
electroencephalogram) without sedation. A recent study showed that
people taking measured doses
of a kava extract fared better in word-recognition tests than those
taking a synthetic tranquilizer
(benzodiazepine), and a 1993 report in the British Journal of
Phytotherapy referred to kava as one
of few herbs that can safely relax skeletal muscle. The report's author
recommended it for treating
nervous tension and conditions associated with skeletal muscle spasms,
such as headaches
caused by a tense neck.

In 1996, a randomized, placebo-controlled, double-blind study showed
that kava significantly
reduced anxiety in humans. Two groups of twenty-nine people with normal
anxiety were treated for
four weeks with three daily doses of 100 mg of kava rhizome extract or a
placebo. After one week of
treatment, members of the kava group had significantly lower anxiety
levels compared with that of
the placebo group, and the difference between the two groups increased
during the course of the
study. No adverse reactions to the kava extract were noted during the
study.

A 1995 report, however, described four patients who experienced
unpleasant side effects from using
various kava preparations. A twenty-eight-year-old man, who had been
taking pharmaceuticals for
treatment of anxiety, had sharp spasms in the muscles of his neck and
eyes that began about ninety
minutes after taking 100 mg of kava extract and lasted about forty
minutes. A twenty-two-year-old
woman experienced a similar reaction to the same product but denied
taking any other medication,
as did a sixty-three-year-old woman who had taken 150 mg of kava extract
three times daily for four
days to treat anxiety. Finally, a seventy-six-year-old woman with early
signs of Parkinson's disease
(a disorder of the nervous system) reported a pronounced increase in the
duration and number of
episodes of impaired movement after switching from pharmaceuticals to
150 mg of kava extract,
which she took twice a day. The study's authors suggested that kava
products be used cautiously,
especially in the case of elderly patients.




Kava-kava

(kava)

Piper methysticum

--
Ron Vetter 1936, '84 PD dz
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http://www.ridgecrest.ca.us/~rfvetter