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hi charlie At 11:17 1998/12/11 -0600, you wrote: >LISTFRIENDS: >I have been asked by a former listmember, who is a physician and PWP in >Rome Italy to post the question on the list whether anybody knows any >references or has had personnal experience with PD while being >pregnant. I will forward all responses to him. i did a preliminary dig at PubMed at: <http://www.ncbi.nlm.nih.gov/PubMed/> ------------------------------------------------------ Mov Disord 1998 Jan;13(1):175-6 Selegiline, pregnancy, and Parkinson's disease. Kupsch A, Oertel WH Charite Virchow Clinic, Humboldt University, Berlin, Germany. No abstract available. PMID: 9452347, UI: 98112726 ------------------------------------------------------ Mov Disord 1998 Jan;13(1):34-8 Pregnancy in Parkinson's disease:=20 a review of the literature and a case report. Hagell P, Odin P, Vinge E Wallenberg Neuroscience Center, University Hospital, Lund, Sweden. Abstract: Pregnancy is rare in Parkinson's disease (PD). In the literature= on studies of antiparkinsonian drugs in animals during pregnancy, there are= reports on malformations of the skeletal and circulatory system. However,= the majority of studies in animals have not shown any teratogenicity.= Amantadine has been teratogenic in rats and selegiline has caused= neurochemical and behavioral alterations in rats when coadministered with= clorgyline. The published experience with humans consists of 35 pregnancies= among 26 women suffering from PD, including this report, and a number of= cases treated with antiparkinsonian agents for other reasons. With the= exception of the majority of the cases where amantadine was used,= complications have been rare. However, there are indications that suggest a= possible risk of a woman's parkinsonism worsening in connection with= pregnancy. We also report the case of a woman with PD who was treated with= L-dopa-benserazide during an uncomplicated pregnancy and gave birth to a= healthy boy without experiencing any worsening of her PD. PMID: 9452323, UI: 98112702 ------------------------------------------------------ Ugeskr Laeger 1991 Apr 22;153(17):1210-1 [Pregnancy and Parkinson disease]. [Article in Danish] Tobiassen C, Brasso K, Kohler OM Amtssygehuset i Roskilde, gynaekologisk-obstetrisk afdeling, Denmark Abstract: Parkinson's disease rarely occurs in women of the fertile age. A= case in a woman aged 42 is reported. The diagnosis of Parkinson's disease= was established three years before her second pregnancy. Medicinal= treatment with antiparkinson drugs during pregnancy is briefly discussed. PMID: 2028535, UI: 91228265 ------------------------------------------------------ J Gynecol Obstet Biol Reprod (Paris) 1990;19(4):461-3 [Parkinson disease and pregnancy. Apropos of a case]. [Article in French] Jacquemard F, Palaric JC, Allain H, Giraud JR Service de Gynecologie-Obstetrique A, Hotel-Dieu, Rennes, France Abstract: Parkinson's disease is a neurological condition associated with= neuronal degeneration in the corpora nigra with a drop in the level of= dopamine in the striatum. It is rarely encountered in women of reproductive= age. Treatment is by giving levodopa. We report a case of pregnancy in a= woman of 34 years of age who was suffering from severe Parkinson's disease= treated with levodopa. We have assessed this case in the light of viewing= the literature which confirms that there is no effect on the pregnancy or= on the fetus although the symptoms of Parkinson's disease are made worse.= Levodopa seems to be quite innocuous as far as the fetus is concerned.= There is no teratogenicity although in animal experiments high doses= teratogenic effects have been noted. PMID: 2199565, UI: 90338678 ------------------------------------------------------ Neurology 1987 Jul;37(7):1245-9 Parkinson's disease and pregnancy. Golbe LI Abstract: In an effort to study the interaction of pregnancy and Parkinson's= disease (PD), I interviewed 18 women who had had a total of 24 pregnancies= after onset of PD symptoms. Conception occurred at mean age 34.7 (SD 6.1)= years. There were 3 miscarriages, 4 elective abortions, and 17 term= pregnancies. Use of amantadine during the first trimester was associated= with a heterogeneous group of obstetric complications including= miscarriage. Ten of the 17 completed pregnancies were associated with= permanent worsening of PD symptoms, which did not affect overall= disability. Among the series as a whole there was no excess incidence of= obstetric complications or fetal defects. PMID: 3601093, UI: 87258806 ------------------------------------------------------ i'd be happy to dig further if you think it would be useful your cyber-sibling in archy-ology janet janet paterson - 51 now /41 dx /37 onset - almonte/ontario/canada [log in to unmask]