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Hi Ted: We have similar conditions; I take Sinemet CR 50/200 and have just started Mirapex. Question: My greatest problem is tremor. About how long did the Mirapex take before you noticed an improvement with tremor reduction? I've only been on it for a week but we're hopeful. John Carole K. Menser wrote: > I am new to the list. My name is Ted Menser and I live in Redding > Ca..I found out I had Parkinson's over 6 years ago. I was diagnosed > at age 46 and am currentlt 51 My current medications include > Sinement 50/200, Mirapex 100mg, amatadine 100 mg. Mirapex is a new > medication and has helped a great deal. I currently have no noticeable > shaking at rest and my two main problems are extreme fatigue after two > hours of work which requires for approx. 45 minutes and it has become > more difficult to move. I drive and can do everything but in limited > time frames. I was able to finish a 30 year career and retired from > the Postal Service as Postmaster of Redding. Ted