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Ciao dear listmembers! After sending my message on 17 November and the answer by Debbie White, I've searched on Pubmed some more information about use of Growth Hormone in PD therapy. I didn't find anything; but there were 3 research rather interesting, whose 2 at Parma University, in Italy. I've sent an e-mail to the research leader, Prof. Riccardo Volpi, with 3 questions: 1. Is GH (at very low doses) helpful for PD patients, having IGF-1 level lower than normal? 2. Do you know if and where this therapy is tried? 3. Is GH safe? What are the risks? This is a summary of the answer by Prof. Volpi. "In Parkinson's disease, after stimulation with specific factor (GH-RH), the production of Growth Hormone (GH) is normal, but some systems of stimulation of GH-RH seem to be not fully efficient. A research of ours about it is going now. A low production of GH because of a lower effectiveness of stimulation systems might cause symptoms, such us drowsiness, easiness to fatigue, low level of glicemy. Any year ago, the use of GH or of GH-RH was proposal in anti aging therapy with great effectiveness. The results were published on prestigious "New England Journal of Medicine" Today there are specific clinical trials for osteoporosis and miocardiopatyas. Not all patients may use this therapy, because side effects could be dangerous (for ex. diabetes mellito- I don't know the meaning of the last word)." I hoped to have better news! Some interesting news about GH are in the message sent by Christine Anderson from New Zealand too. In fact, IGF-I is the most common marker of the GH level in the blood. I dislike that Prof. Gluckman's clinical trials with IGF-I concern only MS and not PD too! Here, I add what Dr. Marko B. Lens (an American doctor, working in Milan, Italy) wrote in a book about GH, published in last February: "Scientists of Auckland University have discovered that IGF-I can stop the neuronal death. With other words, it can block apoptosis, the death of neuron programmed by the biological internal clock. This happen during the aging, or in diseases, as stroke, AD, PD and MS." Ciao and a merry Christmas to you and your families! Massimo Paolini Roma, Italia cg of mother Anna 70/64/62.