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Internal pallidum stimulation effective for "off" states in Parkinson's disease WESTPORT, Dec 21 (Reuters Health) - Bilateral high-frequency stimulation of the internal globus pallidus significantly improves symptoms of Parkinson's disease during the medication "off" state. Dr. J. Volkmann of Heinrich-Heine-University in Dusseldorf and colleagues there and elsewhere in Germany conducted a pilot study to examine the efficacy of stimulation in nine patients with severe Parkinson's disease with on/off fluctuations. http://ipn.intelihealth.com/ipn/ihtIPN?c=205029