Hi Judith, I agree with others that your friend seems overmedicated and is also reacting to so many changes. I am also puzzled by the contention that regular Sinemet is "too hard on the system." I was put back on regular Sinemet (by a well-known MDS) because my system found CR to be hard on me and tended to make me even more dyskinesic. I sometimes wonder if one takes more of an agonist than actually needed by one's present level of levadopa/carbidopa, if that sets up the system to "think" that now more Sinemet is needed--thus leading to a vicious cycle. What do others think? Barb -- Barbara Blake-Krebs in KS 58/44 [log in to unmask]