Ivan M Suzman wrote: > Morphine by nose in a tube seems drastic, doesn't it? This was an error on my part, (I was so tired). The morphine was to be given by injection. Barbara Blake-Krebs wrote: >I am also puzzled by the contention that regular Sinemet is "too hard on the system." That puzzled me, too. >I was put back on regular Sinemet (by a well-known MDS) because my system found CR to be hard on me and tended to make me even more dyskinesic. This was my experience also. My friend seemed slightly improved today. He actually had some reasonably good "on" time this morning and with the help of a P.T. was able to walk a short distance. The only difference made to his medsat that point, was the addition of 100 mg of amantadine first thing in the morning. However, shortly after lunch he went "off" again and his muscles and joints stiffened noticeably. I have just had a call from his wife, and he has not had any "on" time since. The nights seem to be worst. When we were in Emerg. on Sunday evening, we stopped trying to give him his meds at 7 pm (he was taking Sinemet hourly) because it was too difficult for him and us. He was finally taken to his room about 11, and he wasn't any worse for not having had his meds during that time. It seems that as the day progresses, the meds build up and his system shuts down. His wife was able to contact the MDS, (who is still away), and he has had the Requip cut back by half, and plans to get him off it altogether. I believe he wants to keep things at this point, if possible, until he gets back on January 4 At this point my friend is taking 1 Sinemet, 100/25 every hour from 6 am till 10 pm, and at least one during the night, 100 mg amantadine, half the Requip (whatever), 25 mg amitriptyline, and Tylenol (don't know how much) and Ativan. Tomorrow is another day. Thank you for all the help. It was needed and very much appreciated. Judith -- Judith Richards, London, Ontario, Canada <[log in to unmask]> ^^^ \ / \ | / Today’s Research \\ | // ...Tomorrow’s Cure \ | / \|/ ```````