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On Tue 05 Jan, Sharon & Jim LeBlanc wrote: > Glutathione Reductase deficiency or GR red is involved with all forms of > parkinson's syndromes including low levels of glutathione, low vitamin E, > low vitamin C, low phosphorylated B vitamins, increased superoxide > dismutase mangangese, High manganese gives you PD, low P450, which effects > many drugs including antihypertensives, low NADP-ferridoxin reductase > destroyed by herbicides, low ubiquitin oxidoreductase, it blocks inhibition > of adenylate cyclase just like pertussis, it prevents decarboxylation of > dopa to dopamine. It prevents chelation of all free metals, increases PIP2 > and causes depression, increases intracellular calcium, which can cause > kidney stones, decreases leukotrienes, causing skin diseases like seborrhea > dermatitis and psoriasis, causes the inability to break down fatty acids, > decreases the effectiveness of insulin receptors and can bring on adult > onset diabetes, it increases T-cells, histamine, IgE cells, increases > cyclooxygenase and inflammation effected by NSAID meds that exacerbate PD. > It can be partially made by the malarial parasite plasmodium falciparum. Do > you know any drug company trying this treatment for parkinsons? > [log in to unmask] > > > Hello Jim, I don't pretemd to understand all the terms which you list in your e-mail, but I suggest that the points listed below may be relevant. I understand that Amantadine, (that anti-viral agent which worked although nobody could explain why) actually works by inhibiting the glutamine system. Almost a year ago, I took part in a preliminary trial of a drug called Remacemide - A glutamate antagonist which is claimed to improve Dopamine levels by inhibiting glutamate production, which in turn inhibits depletion of Dopamine levels. Unfortunately, I discovered that I had been given a placebo, but I gather that changes of quite significant magnitude were experienced by other people in the trial. -- Brian Collins <[log in to unmask]>