Lisa... You may want to try taking 1/2 a tablet of Sinemet for your initial dose of the day rather than a whole tablet, and DO take it with a sweet beverage - fruit juice, a soda pop, sweetened tea, etc., as it's a well known fact that for some reason Sinemet, taken with a sweetened beverage seems to kick-in more smoothly and a bit faster (oddly tho, there seems to be no known reason WHY it works better when taken with a sweet beverage or even a teaspoon of ice cream or sherbet) FYI (just an example of an alternate drug schedule).... It made a significant POSITIVE difference in my life when I started breaking my Sinemet 25/250's in half and took a HALF to start my day's meds. THEN - 1/2 hour later, I took a Sinemet CR 50/200. By the way, no neurologist ever suggested splitting the Snippets to me. THEY have always said to take a higher dose and/or to take the meds more frequently. Warm hugs and lotsa love to you, Lisa. And please keep us updated on how you're doing, 'kay? We care... Barb Mallut [log in to unmask] -----Original Message----- From: LISA CRUMRINE <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Date: Wednesday, January 06, 1999 1:37 AM Subject: WORSENING SYMPTOMS(this sucks) >DEAR list folk, >I sit here at the computer at 4;30 am barely able to type because of my left >side shaking so. It seems like my symptoms have progressed in the last >month or two. It sucks, to watch my physical condition worsen, I am 40 >years old, I am in excellent physical condition other wise, the shaking (in >the morning) doesn't stop for at least 2-3 hours after I take my meds (1 >sinemt 25/100cr & 2 permax .25 & eldepryl) at awakening. then it seems like >it lasts for an hour (the on time) and it's time to take more drugs , >hopefully in time so they kick in before the next bout with pd. it really >sucks sometime, I try to keep a positive attitude, my friends are great. my >boyfriend is wonderful. but how do we keep our shit together in times >like this, yesterday was rough, today so far ( it's 5;15 am) is not good, I >sit here typing and cant control my body, I cant be a rock all the time, I >cant let loose my emotions on to my friends cuz they dont know how to >respond (how can they) and it is hard on them cuz they feel helpless. >I hate this disease and what it does to me! I WANT MY BODY BACK! I dont >have faith that any drugs are going to make it better, cuz they dont, they >just offer a different set of side effects. oh what fun trying to figure >out the exact chemical balance and timing that will work (for an hour). I AM >FRUSTRATED! I AM DEPRESSED! >I AM SORRY to dump this on you guys, but thank god your here >withlove and appreciation for this list >Lisa 40/6 St. john usvi >