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hi again lisa something i missed the first time around: At 05:23 1999/01/06 -0500, you wrote, in part: >It sucks, to watch my physical condition worsen, I am 40 years old, >I am in excellent physical condition other wise, the shaking (in the >morning) doesn't stop for at least 2-3 hours after I take my meds >(1 sinemt 25/100cr & 2 permax .25 & eldepryl) at awakening. then >it seems like it lasts for an hour (the on time) and it's time >to take more drugs, hopefully in time so they kick in before the >next bout with pd. if you feel no benefit from the sinemet controlled release [cr] for two to three hours after taking it that's normal for an early morning 'kick-start' many parkies on sinemet cr have been advised to take a half tablet of 'instant'or regular sinemet in addition to the cr the theory being: the 'instant' sinemet would 'kick-in' within half an hour and as i recall, has a half-life of about 2 hours in the body [vs a half-life of about 4 hours for the cr version] so by the time its effect is wearing off the sinemet cr would be 'kicking-in' fine-tuning our meds can be a chore but is critical to our functioning no one else knows how we feel if your pd symptoms are 'showing through' sometimes then you are probably slightly under-medicated at those times i use regular sinemet almost exclusively because i need to 'fine-tune' very closely [half of a 10/100 tablet every 90 minutes] i find that cr is much more difficult to 'tune' ...just another thought for whatever it's worth love janet janet paterson - 51 now /41 dx /37 onset - almonte/ontario/canada <http://www.newcountry.nu/pd/members/janet/index.htm> [log in to unmask]